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CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

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Immunomodulatory Properties Quercetin stimulates T-helper cells to produce (Th-1)-derived Interferon- (IFN- ) and downregulates Th2-derived IL-4 when added to cultured blood peripheral mononuclear cells (87, 88)

Among the various compounds synthesized, the alkyl-based PROTAC 73 stands out, capable of inducing in vitro a selective and potent proteasome-dependent degradation of the target protein (DC 50 value of 214 nM), resulting in a favorable antiproliferative effect (IC 50 value of 1.3 M) 128

Some procedures, such as lasers or chemical peels, are not advised during these stages due to safety concerns