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mTORC1 is well known to be controlled by variations in levels of ATP, amino acids, oxygen, DNA damage and oxidative stress [74]

J Neuroendocr

Physiol Mol Biol Plants 19:6979 Thordal-Christensen H, Zhang Z, Wei Y, Collinge DB (1997) Subcellular localization of H 2 O 2 in plants

By treating metabolically active adipocytes and hepatocytes with 5-amino-1-methylquinolinium, researchers can precisely inhibit intracellular NNMT activity, monitor changes in the nicotinamide pathway and NAD+ levels, and analyze effects on energy metabolism