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For example, in a randomized, double-blind, placebo-controlled trial in 60 participants diagnosed with an acute MI, neither mortality nor echocardiographic measures of cardiac function differed between patients treated with intravenous L-carnitine (6 g/day) for seven days followed by oral L-carnitine (3 g/day) for three months and those given a placebo (49)

Author Contributions Concept and design: Ramy Elantary, Samar Othman Drafting of the manuscript: Ramy Elantary Supervision: Ramy Elantary Critical review of the manuscript for important intellectual content: Samar Othman References 1.Global burden of cardiovascular diseases and risk factors, 1990-2019: update from the GBD 2019 study

Secondary genetic carnitine deficiency CPT-1 deficiency Carnitine palmitoyltransferase I (CPTI) deficiency is thought to cause serious disorders of fatty acid metabolism

Stay Consistent: Like many supplements, L-Carnitine works best when taken regularly over time and not just occasionally

Symptomatic treatment for PAD adds maximal risk factor modification, exercise, and, when indicated, invasive treatment using balloon angioplasty with or without stenting and bypass surgery together