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10.1007/s00018-019-03085-6 105 KawanoM.NagataS

The BBB is referred to as a carrier because of its ability to transport the necessary nutritional molecules like vitamins, minerals, glucose, lipid-soluble molecules, and gases such as carbon dioxide and oxygen present in the blood to the brain as well as helping the elimination of toxins/metabolites [3]

Building on these findings, BL-based therapeutics, including heme-derived nanoparticles, are currently under investigation for their capacity to modulate neuroinflammation and oxidative stress in neurodegenerative disorders (Yin et al., 2022)

229 In osteoporosis, MSCs tend to favor adipogenic differentiation, which reduces bone formation and increases fat accumulation within the bone marrow, thereby exacerbating bone loss and increasing the risk of fractures

Stable in gastric juice and resistant to acidic degradation