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Bevacizumab combined with docetaxel, oxaliplatin, and capecitabine, followed by maintenance with capecitabine and bevacizumab, as first-line treatment of patients with advanced HER2-negative gastric cancer: A multicenter phase 2 study

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The CON-39 C HS group, 39 C HS -39 C DF group, and 39 C HS -39 C HX group were screened for 129 (mainly nucleosides, nucleotides and analogs, lipid and lipid-like molecules, organic acids and their derivatives, and organic heterocyclic compounds), 121 (mainly nucleosides, nucleotides and analogs, organic acids and their derivatives, organic heterocyclic compounds, lipid and lipid-like molecules), 83 (mainly lipid and lipid-like molecules, benzene ring-type compounds, organic acids, and their derivatives) differential metabolites, respectively

Studies have demonstrated that celastrol inhibits the PI3K/AKT/mTOR signaling pathway, increases the autophagosome level of FLS, decreases the phosphorylation of mTOR and AKT, and induces autophagy, thus ameliorating RA (234)

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