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To be modifiable, the Cys must have a low pKa, a property that is largely determined by the electrostatic environment of the protein context

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Modifying ligands can enhance receptor-ligand interactions between NPTAs and the BBB surface, hence promoting the penetration of NPTAs through the BBB [74]

CrossRef Effect of 21-Day Omega-3 Polyunsaturated Fatty Acid Supplementation on Exercise-Induced Secretory Factors and Inflammation Status in Young Men: A Randomized Double-Blind Trial Magdalena Konert, Paulina Brzeziska, Andrzej Kochanowicz, Elbieta Piskorska, Baej Stankiewicz, Ewa Polkowska, Tomasz Sledzinski, Adriana Mika, Jdrzej Antosiewicz, Jan Mieszkowski Nutrients.2026