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In vitro studies have demonstrated that the iron overload induced by ferric ammonium citrate triggers ferroptosis in NPCs and increases MMP expression, accelerating ECM breakdown (5,33)

These can include antidepressants, antipsychotics, and some sleep medications

This relationship may reflect the fact that people who reported initiating kratom use to self-treat addiction symptoms often experienced kratom withdrawal symptoms when they tried to discontinue use