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This cream is a semisolid preparation that is dispensed in a pump mechanism, which allows for convenient, hygienic, and controlled application

Importantly, two research groups demonstrated that Set7/9-mediated methylation of Hif1a under hypoxic conditions increased the proteasomal degradation of Hif1a and hence prevented transactivation of Hif1 target genes 105 , 106 (Figure 2B)

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