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Over years, the hairline starts to creep back, and the crown may show reduced hair density

These models have provided a service in the development of therapies for Graves disease, including immune-modulatory treatments targeting autoimmune components of the disease, and thus laid the groundwork for therapeutic advances in human patients (Kahaly 2020)

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These large-scale changes in turn reorient the N-lobe and the C-lobe of the kinase domain to fine-tune the kinase active site in a catalytically optimal geometry

However, only five diagnostic studies met the adopted criteria (Table 1)