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10.1074/mcp.M110.006866 45 GilleryP

To investigate the transcriptional regulatory effect of Gln on the GGCT gene, a 2000-bp sequence of the GGCT gene promoter region was inserted into the pGL4-Basic vector

The symptoms come and go in a cycle, known as a wax and wane, or a relapsing-remitting course of symptoms in Lyme disease

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Compared with JAK and TYK2 inhibitors, which exert potent downstream modulation, compounds such as baicalin and EGCG exhibit only partial JAK/STAT or PDE-like immunomodulatory activity, and crucially, they lack human-grade PK/PD validation [36, 37]