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Ferroptosis and the ubiquitin-proteasome system: exploring treatment targets

Abbreviations ACE: Angiotensin-converting enzyme ANGPT2: Angiopoietin 2 ANGPTL4: Angiopoietin-like 4 COX: Cyclooxygenase CVD: Cardiovascular disease DAMP: Damage-associated molecular pattern DHA: Docosahexaenoic acid EPA: Eicosapentaenoic acid ET-1: Endothelin-1 EPC: Endothelial progenitor cell FFA: Free fatty acid FABP: Fatty acid-binding protein CD36: Cluster of differentiation 36 FATP: Fatty acid transport proteins LCFA: Long-chain saturated fatty acid LCPUFA: Long-chain polyunsaturated fatty acid LDL: Low-density lipoprotein MYC: V-Myc avian myelocytomatosis viral oncogene homolog NO: Nitric oxide PPAR: Peroxisome proliferator-activated receptor alpha PPAR: Peroxisome proliferator-activated receptor-gamma PG: Prostaglandin PUFA: Polyunsaturated fatty acid RAS: Renin-angiotensin system ROS: Reactive oxygen species SREBP-1c: Sterol regulatory element-binding protein 1c SERCA: Sarco/endoplasmic reticulum calcium ATPase Tx: Thromboxane TNF: Tumor necrotic factor TLR: Toll-like receptor References Chlopicki S (2015) Perspectives in pharmacology of endothelium: from bench to bedside

immune and inflammatory crosstalk

All recipients maintained normoglycemia for 3 years without extra insulin treatment