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Studies have shown that hepcidin can enter the central nervous system through the BBB (Raha-Chowdhury et al., 2015), which, with increased permeability after TBI, may allow a large amount of hepcidin to the brain tissue

Methods: MASH was diagnosed based on the presence of metabolic dysfunction and steatohepatitis

Hypertrophy of the intima and media, sclerosis of the vascular wall, and the formation of atheromatous plaques are structural changes in the renal vessels due to aging, similar to the changes observed in vessels in other organs of the body

4 Strengths and limitations This review integrates evidence across cellular, organ, and physiological levels, highlighting autophagy pathways, hormonal regulation involving GH, cortisol, insulin, leptin, and thyroid hormones, as well as cardiovascular, neurological, and gastrointestinal outcomes