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This evidence supports the off-label use of botulinum toxin as a novel therapeutic strategy for KOA management in orthopedic practice (107)

Furthermore, not including a third intervention group receiving synbiotic plus placebo, could be considered as the other limitation of this study

H., Lu, J

Thus, the nutrient-microbe-host meta-organismal framework linking diet and microbial metabolism to fibrosis represents a targetable pathway for therapeutics, and it will be interesting to see if selectively inhibiting microbial TMA lyase translates to a decreased propensity of fibrosis

Ko SJ, Kang NH, Kim MK, Park J, Park E, Park GH, Kang TW, Park JB, Yi YE, Jeon SH, Park Y (2019) Antibacterial and anti-biofilm activity, and mechanism of action of pleurocidin against drug resistant Staphylococcus aureus