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burgdorferi lacks genes encoding enzymes necessary for nucleic acid, amino acid, and fatty acid biosynthesis

doi: 10.1093/femspd/ftad001 87 SheP.LiuY.XuL.LiY.LiZ.LiuS.et al

No recognized detoxification methods or technical systems have been established, and the Chinese Pharmacopoeia (2025 Edition) does not include standard detoxification procedures for these TCMs

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Similarly, the stem cell factor SOX2 directly binds and activates the SLC7A11 promoter to confer ferroptosis resistance in lung cancer stem cells, which can be abrogated by SOX2 oxidation at Cys265 [31]