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Moreover, KO mice for liver IGF-1 gene developed muscle insulin resistance (it is important to mention that skeletal muscle myocytes express high number of IGF-1R), showing an increase in insulin concentrations and a substantial decrease in the insulin-induced autophosphorylation of the insulin receptor and IRS in skeletal muscle (being normal in liver and white adipose tissue)

A helium bag was used between the sample, crystals and detector to minimize attenuation of the fluorescence from air and reduce background from diffusely scattered radiation

10.1128/spectrum.02124-21 138 XieS.ZhaoS.JiangL.LuL.YangQ.YuQ.et al

The mechanism of nerve growth and hyperinnervation of pathologically painful disc has not been fully clarified