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In clinical practice, bone defects are typically repaired using autografts, allografts, and xenografts

366,453,454 The relationship between these structural and functional brain changes and metabolic factors remains poorly understood, with potential mechanisms including vascular injury, oxidative stress, osmotic imbalances, and glial and neuronal damage

The individual evidence for each compound is substantial and replicated in animal research, but the rationale for pairing them is mechanistic: it is based on what each does on its own, not on a study of the combination

Once-daily dosing offers simplicity and better compliance, while split dosing theoretically maintains more stable tissue concentrations throughout the day

Chitosan coated MOF/GO nanohybrid as a co-anticancer drug delivery vehicle: synthesis, characterization, and drug delivery application