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Cancer Cell 44(1):24-49, 2026

We also demonstrated that this complete Ube3a deletion in MEFs affected the proliferation and apoptosis capacity of these cells [29, 30]

Even a 5 year delay in progression would drastically reduce the number of people affected, saving the health care system billions and preserving the quality of life of affected individuals

Apart from these intrinsic, extrinsic and stress-induced processes, there exists an additional pathway that entails T cell mediated cytotoxicity and perforin/granzyme-dependent cell death