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Short peptide sequences: current knowledge and future prospects

10.1016/j.semcdb.2017.12.003 34 DengY.ChangC.LuQ

Furthermore, it is crucial to consider the investigation of subclinical alterations, whether genetic or metabolic, that may necessitate higher thiamine levels than what current testing parameters indicate [7]

GSH production is supported by NRF2 through controlling several enzymes responsible for GSH synthesis, such as the glutamate-cysteine ligase (GCL) complex composed of two subunits, the modifier (GCLM) subunit and the catalytic (GCLC) subunit, which catalyze the rate-limiting step of GSH synthesis that converts cysteine and glutamate into GSH [22]