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It binds with high affinity to HGF inducing dimerization and Met phosphorylation in the presence of subthreshold levels of HGF [Figure 2] [74]

To confirm the role of ROS in chaetocin/TRAIL-induced apoptosis, cells were pretreated with 5 mM NAC, a ROS scavenger, prior to treatment with chaetocin and TRAIL for 6 h