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5 Abnormal mitochondrial quality control in neurodegenerative diseases Neurodegenerative diseases are chronic neurological disorders that are characterized by selective neuronal degeneration and neuronal loss or death

This suggests that the co-treatment with ferrous iron again switched the signaling mechanisms and mode of cell death from mitochondrial dysfunction-dependent necrosis after APAP alone to LPO-dominated ferroptosis after APAP + Fe 2+ (Figure 1)

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