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Because of its history of safe use, few populations should avoid using GHK-Cu

10.1038/s41590-020-0699-0 Nat Immunol

They are small enough to target specific biological processes gently without triggering a medication-only mindset

3.3 Changes in serum cobalamin by supplementation route and dosage Across 35 comparisons, the mean percentage increase in serum cobalamin following supplementation was approximately 293%, confirming the overall effectiveness of vitamin B12 interventions (Supplementary Table S4)