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In a randomized, placebo-controlled study of 495 patients with intermittent claudication, 2 g/day of propionyl-L-carnitine for 12 months significantly increased maximal walking distance and the distance walked prior to the onset of claudication in patients whose initial maximal walking distance was less than 250 meters (m), but no effect was seen in patients who had an initial maximal walking distance greater than 250 m (65)

Based on this current clinical evidence, long term usage of LC should be strict avoided and one must not exceed the daily allowance to avoid the short term side effects as well as the risk of long term complications due to prolonged elevated TMAO levels

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