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Specifically, BPDE can induce global hypomethylation by inhibiting DNA methyltransferases (DNMTs), which leads to the upregulation of oncogene expression and downregulation of tumor suppressor gene function, thus promoting the proliferation and metastasis of bladder cancer cells (Bukowska and Siciska, 2021

doi: 10.1194/jlr.R700017-JLR200

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