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These groups can then address new combinations of polymers in a single nanoscaffold and promote the ad-hoc functionalization with targeting biomolecules to obtain selective and controlled release of therapeutics, proteins or nucleic acids to specific brain areas (Michaelis et al., 2006

doi: 10.1089/can.2016.0027

found that puerarin could increase the melanin content of melanocytes in vitro , and topical application could improve the melanin content of mouse skin tissue, the mechanism is via activation of the cAMP pathway, followed by elevation of MITF, tyrosinase, Trp-2, and Bcl-2 to increase melanocyte survival and melanin content (Park et al., 2014)