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[16] In nature, acyclic carotenoids occur mainly in the s- trans conformation, as it has the least steric hindrance

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Moreover, ferroptosis can propagate through intercellular mechanisms involving the release of damage-associated molecular patterns (DAMPs), dysregulation of immune checkpoints, and exosome-mediated signaling, collectively driving microglial activation, T-cell infiltration, and bloodbrain barrier disruption, culminating in systemic immune imbalance