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The P65 subunit of NF-B was indeed found to be bound to the two putative NF-B binding motifs within the EAAT3 promoter

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Their findings underscore the critical role of the lactate/H3K18la/NFB/IL-6 and IL-8 pathways in both aging and AD [76]

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2291-C DASATINIB AND QUERCETIN AS SENOLYTICS ATTENUATE FAT DEPOSITION AND HAVE ANTIFIBROTIC EFFECTS IN MEDAKA NONALCOHOLIC STEATOHEPATITIS MODEL Hiroyuki Abe 1 , Shunta Yakubo 1 , Norihiro Sakai 1 , Yusuke Watanabe 1 , Naruhiro Kimura 1 , Toru Setsu 1 , Takeshi Yokoo 1 , Akira Sakamaki 1 , Hiroteru Kamimura 1 , Atsunori Tsuchiya 1 , Kenya Kamimura 2 and Shuji Terai 1 , (1)Graduate School of Medical and Dental Sciences, Niigata University, (2)School of Medicine, Niigata University Background: Non-alcoholic steatohepatitis (NASH) is known to cause cellular senescence due to the effects of oxidative stress, endoplasmic reticulum stress, and autophagy in the liver caused by ectopic fat deposition