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Critically, SCFAs are master epigenetic regulators, acting as inhibitors of the enzyme histone deacetylase (HDAC), which is involved in the histone modification [194, 195]

thaliana GSTUs were associated with the response to environmental cues

Importantly, this immunosuppression is rapid and reversible, and buffering extracellular acidity can restore CTL function even in the presence of high lactate levels [211]