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assay for DNA cleavage or mutation at the target sequence, or assay for altered gene expression activity affected by CRISPR complex formation and/or CRISPR enzyme activity), as compared to a control no exposed to the CRISPR enzyme or complex, or exposed to a CRISPR enzyme lacking the one or more NLSs

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Improved mitochondrial integrity and DNA repair

Said-Elbahr R, Nasr M, Alhnan MA, Taha I, Sammour O