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Food Chem 113(4):859871

Liver toxicity may result from an acute overdose as well as from repeated supratherapeutic ingestion

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Another study has indicated that the C3-mediated protective effect on pancreatic islet cells involves AKT activation and c-Jun N-terminal kinase (JNK) inhibition upon treatment with pro-inflammatory cytokines, such as IL-1 and IFN- (178)