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10.1016/S0140-6736(16)32404-7 36 LeeS.MoonS

We selected the G12D and G12V mutations because of their high frequency across all KRAS-driven cancers (including colorectal cancer) (Figure S1A), G12C for its high prevalence only in lung adenocarcinoma, and G12A because it is infrequently observed in colorectal adenocarcinoma yet biochemically indistinguishable from G12V 7

The substrates and products of the DHODH reaction have opposite effects on ferroptosis, suggesting that the potential role of DHODH in regulating ferroptosis sensitivity is independent of its function of producing pyrimidine nucleotides

doi: 10.1080/15548627.2019.1687210 344 WuTLiuYCaoYLiuZ

IL-1-mediated repression of microRNA-101 is crucial for inflammation-promoted lung tumorigenesis