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Oxidatively modified nucleic acids in preclinical Alzheimers disease (PCAD) brain

The resulting decrease in the -KG/succinate ratio inhibits the activity of -KG-dependent dioxygenases, leading to a reduction in 5-hydroxymethylcytosine (5hmC) level, epigenetic dysregulation, and ultimately driving tumor cell dedifferentiation and enhanced adaptability [150]

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Such a biological process may result in an acceleration of mental activity

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