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The experience of Charles River Laboratories Phase I clinic over a 10-year period from 1996 to 2005 indicates that the incidence of treatment-emergent Serious Adverse Events in Phase I studies in healthy volunteers is low

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Notably, we did not observe a change in any other fluorescent reporters that measure the activation of other cellular stress responses (supplemental figure 4a-e)

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Hypertens Res 33(1):5661 Reiter RJ, Tan DX, Tamura H, Cruz MH, Fuentes-Broto L (2014) Clinical relevance of melatonin in ovarian and placental physiology: a review