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When UV rays penetrate the epidermis, they damage DNA in skin cells

Pimpin et al., 2018)

Biomaterials 301 , 122284

Structurally, it features a protonated -amino group (NH) and a deprotonated -carboxyl group (COO) at physiological pH, along with a polar carboxamide side chain, classifying it as a polar, aliphatic AA (de Souza Lacerda et al

Studies have found that the methylation of CD44 is correlated with progression and metastasis in prostate cancer (271,272) and Yegnasubramanian et al (273) indicated that the hypermethylation of PTGS2 CpG islands predicted an increased risk of prostate cancer recurrence in 2004