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Subclinical vitamin B 12 deficiency (usually defined as a total serum B 12 of 250 pmol/L), low (150249 pmol/L), and acute deficiency ( 650 pmol/L), such as cancer (Arendt et al., Homocysteine Homocysteine is a metabolite of one-carbon metabolism that is remethylated by MeCbl-dependent MS or betaine-homocysteine methyltransferase as part of the methionine cycle (Finkelstein and Martin, 2)

NAFLD is a metabolic stress liver injury closely related to insulin resistance (IR) and genetic susceptibility, with hepatic steatosis in the liver

This reaction generates hydroxyl radicals, a highly reactive form of ROS, which accelerates lipid peroxidation and cell death