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PUFAs were activated by ACSL4 to generate PUFA-derived acyl-CoAs, and phospholipid peroxides were produced by LPCAT3 (Fig

Oxidative damage of lysosomes in regulated cell death systems: Pathophysiology and pharmacologic interventions

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Data-dependent MS2 fragmentation for compound identification and annotation was performed via the AquireX workflow (Thermo Scientific), which comprised three deep scans with MS1 resolution at 60,000 and MS2 resolution at 15,000