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Previous studies have discovered that drugs could be delivered into brain via the vesicular transport, a vectorial movement across the cerebral endothelial cells from the luminal to the abluminal side 6

To further evaluate whether these predictive markers specifically reflect NAC resistance rather than overall tumor burden, we examined their associations with various clinicopathological parameters in the AMC validation cohort

Nomikou, E., Livitsanou, M., Stournaras, C

Heres the breakdown: C677T Mutation This mutation directly impairs the enzymes ability to produce methylfolate

Glutathione S -transferase P1 (GSTP1), the gene encoding the pi-class GST, is frequently inactivated by acquired somatic CpG island promoter hypermethylation in multiple cancer subtypes including prostate, breast, liver, and blood cancers