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This work suggests that HGF-MET may also protect from parthanatos, a form of caspase-independent regulated cell death occurring especially in neurons and driven by PARP1 hyperactivation (Galluzzi et al., 2018)

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NICE-aligned management typically involves: Addressing modifiable risk factors (smoking cessation, weight loss, increased physical activity, alcohol reduction) Optimising management of underlying conditions (diabetes, hypertension, depression) Trial of PDE5 inhibitor therapy Referral to specialist services (urology/andrology) if first-line treatments fail or where structural/neurological/endocrine causes are suspected Consideration of psychosexual therapy where appropriate Men should be reassured that ED is a medical condition with effective treatments, and seeking help through proper channels ensures safety, appropriate investigation of underlying causes, and access to evidence-based therapies

Collectively, these studies reinforce the versatility of CQDs, however comprehensive in vivo assessments of BBB transport, biodistribution, and long-term neurotoxicity are still required to substantiate clinical translational potential

Third, the intrathecal catheter was sectioned and reattached at the end of the procedure using a connector