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differential diagnosis of genital pigmented lesions has a wide range spectrum like melanosis, melanocytic nevi, seborrheic keratosis, basal cell carcinoma, other diseases such as post-inflammatory hyperpigmentation, lichen planus, Bowens disease, Bowenoid papulosis and most importantly melanoma

Melanoma, on the other hand, is a type of skin cancer that can affect the penis

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Their prophylactic excision is not justified.8,27 AMS has already been described by several authors and institutions based on clinical characteristics of patients and their personal and/or family history of melanoma, with or without histopathological confirmation of an atypical nevus.3 According to Newton et al.1, AMS can be defined through a scoring system, assigning one point for each feature, as seen in Table 1

Understanding these differences can help researchers select the most appropriate compound for their investigative goals