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Majority of the bacterial dehydrogenases relies on the dissociable cofactor PQQ

Duration of response was an additional efficacy outcome measure

T1-weighted MR images (for BBBD assessment) were acquired using a multi-slice multi-echo (MSME, Bruker manufacturer label for a spin echo sequence, in this case with one echo) sequence, before and 5 minutes after administration of 0.2mmol/kg Omniscan via tail vein

BH 2 , an oxidation product of BH 4 , showed similar incremental differences in levels as those shown for BH 4 resulting in BH 4 /BH 2 ratios that indicated preservation of BH 4 levels (Fig