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(PubMed) Zeng T, Zhang CL, Song FY, et al

Thats exactly what your tri-modality method is designed to do

(116) observed that individuals with HLA-DR2 (HLA-DR15 and HLA-DR16) showed significantly increased antiviral antibody titers (herpes simplex type 1, cytomegalovirus, EBV and rubella virus) compared to individuals with other HLA-DR types