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In agreement, in one study (172), significantly higher seminal plasma Se levels in azoospermic men were found, indicating that Se excess in seminal plasma can also be associated with infertility, not only Se insufficient levels

doi: 10.1016/j.molmet.2022.101544 42 ShenYWangXLiuYSinghalMGrkalarCVallsAFet al

however, limited studies have combined more than one DAT in this study

10.1016/j.orcp.2007.07.004 13 ChertokI

Tirzepatide Dual agonist : GLP-1 + GIP Central benchmark for dual incretin research Often discussed in relation to body-weight outcomes, glycaemic control and incretin signalling Single agonist : GLP-1 More selective and mechanistically narrower Common reference point for GLP-1 pathway research Triple agonist : GLP-1 + GIP + glucagon Broader receptor profile than Tirzepatide Often discussed in relation to weight loss, energy expenditure and next-generation multi-pathway metabolic modulation For researchers comparing incretin classes, Tirzepatide often functions as the middle reference point between single-pathway GLP-1 agonists and broader triple-agonist designs