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Another promising strategy is immunotherapy targeting -synuclein [181, 182]

also developed dual pH- and redox-responsive micelles using the synthetic polymers mPEG and polymeric tetraphenylethylene- co -2-azepane ethyl methacrylate [mPEG-P(TPE- co -AEMA) [110]

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Historically, the obesity pharmacotherapy literature notes early trial signals and also that development was terminated after failure to show meaningful weight loss in a larger, longer trial (as summarized in a peer-reviewed review discussing a 12-week signal and a later 24-week negative result)

One study shows that there is a temporal variation in the concentration of the hormone prolactin, with the concentration being highest in the early morning (between 02.01 and 06.00 h)