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Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo

A variety of external factors including nutrients in the environment interacting with genetic susceptibility influence the accumulation of mutations in cells

Cellular and structural biology of the deiodinases

Potential side effects are minimal in studies, but include mild gastrointestinal issues

The most critical aspect of apathy is the decrease of motivation, and several behavioral assays have been proposed to measure the degree of motivation, for example, the progressive ratio task (Spangenberg and Wichman, 2018), the Switchmaze test (Hartmann et al., 2024), foraging arena test (Xeni et al., 2024) or vision depended behavior (Ortiz et al., 2020)