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Calotropis procera attenuates chronic unpredictable mild stress-induced depression in experimental animals

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It takes approximately this long for daily dosing to reach a pharmacokinetic equilibrium, where the rate of drug accumulation from daily dosing matches the rate of elimination

Vogel M, Carlsson MJ, Skowron C et al (2026) Nitrosamine drug substance-related impurities cause DNA methylation adducts in vitro and in primary hepatocytes upon Cytochrome P450-dependend metabolic activation