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Description

63 IkegamiA.ChungP.HanY

T cell receptor alpha/beta expressing double-negative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis

This leads to severe oxidative stress, lipid peroxidation, and catastrophic damage to cellular membranes and mitochondrial DNA, triggering systemic inflammation

Patients should not assume a particular outcome from this treatment

In experimental heart transplantation, NDP-alpha-MSH, a synthetic analogue of alpha-melanocyte-stimulating hormone (-MSH), demonstrated protective activity by influencing various molecular pathways associated with heart function preservation