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PEO can also be attributed to multiple mtDNA deletions or depletion, secondary to nDNA mutations, which follow either autosomal recessive or dominant inheritance patterns and involve genes such as POLG, POLG2, SLC25A4, C10orf2, SPG7, DNA2, RNASEH1, TOP3A, TK2, DGUOK, RRM2B, GMPR, LIG3 , and RRM1

Lastly, although it has been shown that GABA is an HDACi in a neuroblastoma cell line (Xing et al., 2019), in our hands, GABA does not inhibit HDACs to a detectable level in colonic epithelial cells (unpublished)

Though vaccinated individuals are likely to experience milder symptoms compared with the unvaccinated ones, they can still pose as disease carriers for others

References Deumer US, Varesi A, Floris V, et al

For example, in Hordeum vulgare leaves challenged with the powdery mildew fungus, Blumeria graminis , the fungal infection led to a significant decrease in APX and GR activity in whole-leaf extracts of resistant variety but caused no significant change in the susceptible one