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The combined use of MSCs and HA scaffolds more effectively supports IVD regeneration than the use of MSCs or HA scaffolds alone in a rabbit model of IDD (Kumar et al., 2017) enrolled 10 eligible chronic LBP patients who underwent a single intradiscal injection of combined HA derivative and ADMSCs and performed a 12-month follow-up

It was first developed by Professor Vladimir Khavinson, a Russian scientist, in 1980

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Patients in this study ranged from Type II to Type V