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Though traditionally believed not to cross cellular membranes, clinical outcomes suggest otherwise

Cefalo, C.M.A., Cinti, F., Moffa, S., Impronta, F., Sorice, G.P., Mezza, T., et al.: Sotagliflozin, the first dual SGLT inhibitor: Current outlook and perspectives

Diabetic Retinopathy Complications in Patients with a History of Diabetic Retinopathy: Rapid improvement of glucose control has been associated with temporary worsening of diabetic retinopathy

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However, the levels of some commonly used normalizers (e.g., U6 snRNA) were different between control and disease subjects, because U6 expression profiles from young, aging and different disease conditions are variable (Qi et al