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As specifically demonstrated in recent studies on FXN -deficient DRG neurons and patient fibroblasts, treatment with omaveloxolone successfully drives the upregulation of Nrf2 and the GPx4 enzymatic shield

That decline doesnt equal gone. Nutrients can shift from circulation into muscles, nerves, or the liver, where they remain available beyond the blood window

Cell Stem Cell 18 , 229242 (2016)

142 Additionally, inhibition of COX17 leads to elevated mitochondrial copper levels in leukemic stem cells, which results in reduced cellular levels of S-adenosylmethionine, subsequently decreasing global DNA methylation and increasing chromatin accessibility, which contributes to promoting the differentiation of acute myeloid leukemia cells while reducing stem cell-like characteristics

doi: 10.1007/s00592-022-01870-7 89 LiY.SuX