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According to a study in the European Journal of Cardiovascular Medicine, long-term metformin use is associated with vitamin B12 deficiency, a condition with potential hematological and neurological consequences

Clearly, a reduction in MTHFR activity can alter DNA methylation, with research suggesting that individuals who are homozygous for the polymorphism (C677T) in the MTHFR gene have significantly lower levels of methylated DNA when their folate levels are also low

AntiCancer Agents in Medicinal Chemistry

In people with mild deficiencies or people who do not have a deficiency, one B12 shot a week is enough to keep the body working the way its supposed to

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